The Ultimate Guide to Skin Hydration: Science, Insights & Ingredients That Work

Regardless of your age, skin type, or specific concerns, proper hydration is the foundation of healthy, glowing skin. Without it, even the most advanced treatments cannot deliver optimal results.
Skincare has evolved far beyond simply applying moisturiser. Thanks to scientific advancements, we now understand that effective hydration involves a complex network of ingredients working at a cellular level. These ingredients do more than give short term relief to a dry skin or dull complexion—they support the skin’s natural functions, helping to restore, rejuvenate, and protect it from within.
Hydrating your skin strengthens its natural barrier, supports cellular renewal, inhibits pigmentation pathways, and boosts its overall resilience.
In this comprehensive guide, we'll delve into the science behind hydration and hydrating ingredients, breaking down their categories, how they interact with the skin, and how they work together to improve your skin health.
You'll discover which star ingredients deserve a place in your routine, how they function at the cellular level, and the best way to combine them for maximum efficacy.
By the end, you’ll be equipped to read product labels with confidence, tailor your skincare routine, and make informed choices based on your skin’s unique needs.
Understanding Skin Hydration
A Closer Look at How Your Skin Holds and Loses Moisture- And Why It Matters
Whether you’re talking to a skincare expert, reading an article, or looking at a product description online, you’ll often find the term ‘skin hydration’ being tossed about.
Most people nod their heads like they know exactly what it means, but few really understand what it is and how it affects their skin.
Understanding how hydration affects the overall health of your skin helps you to:
- Recognize when poor hydration is causing your skin to struggle
- See how skin hydration affects various skin conditions and concerns and the essential role it plays in treating these disorders.
- Know how different products and ingredients influence your skin and its hydration levels.
- Create skincare routines with the right products that support your skin.
It's time for you to become the skin hydration expert in the room, let's understand…
What Exactly Is Skin Hydration?
Put simply, it refers to the amount of water present in the skin's layers: the epidermis, dermis, and hypodermis.
Skin hydration is essential for maintaining healthy, youthful-looking skin. Beyond its direct impact on the skin’s appearance and wellbeing, it also plays a crucial role in regulating the body's overall water balance.
The skin relies on water to maintain its elasticity, softness, and barrier function, and several factors influence skin hydration:
- Your water intake
- Environmental conditions
- Skincare products you use
- Medications, especially those containing diuretics
- The skin’s natural ability to retain moisture.
Skin hydration occurs through a series of biological processes (natural activities and functions) that work together to maintain the right amount of water in each layer of skin.

The Epidermis and Hydration
The epidermis, — especially its outermost layer, the stratum corneum—acts as the primary barrier between our bodies and the environment. This barrier is like “bricks and mortar”, where corneocytes are the bricks, and intercellular lipids form the mortar. Together, they prevent moisture loss and protect the skin.
Several key components support this barrier and regulate skin hydration:
- Natural Moisturizing Factor (NMF): This collection of water attracting molecules in the stratum corneum helps maintain hydration and barrier function. It consists of amino acids, ceramides, urea, lactic acid, and other humectants that absorb and retain moisture.
Aging, harsh skincare products, and environmental stressors can deplete NMF, leading to dehydration and a weakened barrier.
- Lipids: Ceramides, cholesterol, and free fatty acids, in the epidermis form a seal between corneocytes to reduce trans epidermal water loss (TEWL) and maintain balanced hydration.
When lipid levels decline—because of aging, harsh cleansers, or over-exfoliation—the skin becomes dry, sensitive, and prone to irritation.
Moisturizers containing lipids help restore the skin’s protective barrier and improve long-term hydration.
- Humectants: Substances like hyaluronic acid, glycerin, and NMF components draw water into the skin.
They attract water from the deeper skin layers and the environment into the stratum corneum to keep the cells plump and supple.
Humectants need lipids to be effective. Without them, they can pull water from within the skin, leading to dehydration. Together, humectants and lipids help lock moisture in the skin and maintain healthy barrier function.
NMFs, lipids, and humectants work together in synergy to maintain skin hydration and keep it soft, supple, and resilient
The Dermis and Hydration
Deeper in the skin, the dermis serves as the body’s main water reservoir, helping to maintain moisture levels in the epidermis.
It contains a dense network of collagen, elastin, and glycosaminoglycans (GAGs), which support skin structure and hydration.
One of the most important GAGs, hyaluronic acid, can attract and retain up to 1,000 times its weight in water, keeping the skin plump and hydrated. This hydration-rich environment allows fibroblasts—the cells responsible for collagen and elastin production—to function optimally.
The dermal blood supply also plays a key role in delivering water and essential nutrients to the epidermis, helping to ensure continuous hydration.
When the dermis is well-hydrated, it strengthens the skin barrier, improves elasticity, and helps prevent fine lines and wrinkles.
However, factors such as aging, UV exposure, and dehydration can deplete water-binding components in the dermis, leading to visible dryness and loss of firmness.
The Hypodermis and Hydration
The hypodermis (also called the subcutaneous layer) plays a vital supporting role in skin hydration by regulating temperature and moisture retention.
Composed primarily of adipose (fat) tissue, it helps minimize water loss by reducing evaporation from the deeper skin layers.
Blood vessels in the hypodermis deliver oxygen, nutrients, and hydration to the dermis and epidermis, to ensure moisture reaches the upper layers.
A healthy hypodermis maintains skin plumpness, elasticity, and resilience, helping to prevent dehydration-related sagging and loss of firmness.
However, factors like aging, weight loss, and poor circulation can cause the hypodermis to thin, reducing its ability to support skin hydration and structure.
Aquaporins are special proteins found in cell membranes that act like water channels and allow water to move in and out of cells efficiently. Think of them as “water gates” that precisely control water movement between different skin compartments, responding to the skin’s hydration needs and environmental stressors.
They help transport water and small molecules like glycerol between skin cells, to support skin hydration, elasticity, and barrier function. When aquaporin levels are healthy, the skin stays more moisturized and resilient. Reduced aquaporin activity contributes to dehydration, dryness, and impaired skin repair.
How Dehydration Affects Your Skin’s Appearance and Health
Dehydration sets off a chain reaction that affects both how the skin looks and how well it functions.
When the stratum corneum doesn’t have enough water, the corneocytes shrink and flatten, creating microscopic cracks in the skin barrier. (Think about how mud looks when it dries. As the water evaporates, the clay particles shrink and cracks form. The drier it gets, the deeper the cracks become.) This causes the skin’s protective barrier function to be compromised, making the skin vulnerable and reactive.
These changes are visible as fine lines, especially around the eyes and mouth where the skin is thinner.
Because the skin’s surface is uneven, light doesn’t reflect evenly off its surface, making it look dull, instead of plump, and radiant like well hydrated skin.
On a cellular level, dehydration interferes with the enzymatic processes that are essential for normal desquamation. Without enough hydration, enzymes in the stratum corneum struggle to break down the bonds between corneocytes. As a result, these cells build up on the skin’s surface, leading to a rough, flaky texture.
(To discover more about the importance of healthy desquamation, read our article on The Definitive Guide to Exfoliating Skincare Ingredients.)
When corneocytes build up, they can trap sebum and debris on the skin’s surface and in the pores. This can worsen acne in oily skin, even if the skin is also dehydrated — a seemingly contradictory state.
Chronic dehydration weakens the skin barrier, creating a cycle of ongoing damage. As the skin becomes more permeable, it loses even more water and becomes more sensitive to allergens, pollutants, and other environmental irritants. This water loss, known as Trans Epidermal Water Loss (TEWL), causes further damage to the skin’s barrier function.
One of the biggest concerns about skin dehydration is the cyclical nature of the problem.
Research1 shows that when the skin loses too much moisture, TEWL increases exponentially. This makes it harder for the skin to repair itself and leads to an ongoing cycle of water loss and barrier dysfunction. This problem becomes increasingly difficult to treat without targeted intervention.
Dehydration disrupts the skin’s natural processes, including cellular metabolism and detoxification.
Besides the enzymes required for desquamation, enzymes are required for the other vital functions in the skin.
Enzymes need enough water to function properly; without it, the skin struggles to neutralize reactive oxygen species and harmful molecules and eliminate cellular waste. This buildup of oxidative stress speeds up skin aging by damaging DNA, weakening mitochondria, and breaking down structural proteins.
For those with inflammatory skin conditions like eczema, psoriasis, or rosacea, dehydration can make symptoms worse by triggering the release of inflammatory molecules. This inflammation further weakens the skin barrier, creating another cycle where dehydration and inflammation keep stimulating each other.
Signs Your Skin Needs More Hydration
Dehydration shows up on your skin in various ways. Knowing what to look for helps you tell it apart from other skin concerns and recognize if it’s making existing concerns worse.
Identifying skin dehydration helps you choose the right ingredients and skincare products to treat it properly.

Here are the key signs of dehydrated skin:
- Tight sensation: The skin feels tight, especially after cleansing.
- Fine lines: Fine lines are more noticeable, especially around the eyes and mouth, or they develop prematurely
- Dull appearance: The skin looks dull and lacklustre, with an uneven texture and flaky patches on the surface.
- Uneven makeup: Makeup application is patchy and uneven.
- Increased oiliness: Combination and oily skins that are dehydrated often produce more oil to compensate for the lack of moisture in the skin. Even though the skin is oily, it feels tight, uneven and sensitized.
- Sensitive: The skin looks and feels more sensitive. It is also more reactive to harsh products, changes in the environment, and stimuli.
- Persistent redness: Chronically dehydrated skin often develops persistent erythema because the skin’s protective barrier is damaged.
- Impaired barrier function: The skin stings or burns when applying active ingredients or harsh products. Irritants can penetrate the skin more easily.
- Delayed wound healing: Even minor abrasions take longer to heal in dehydrated skin.
- Increased inflammation: because of the damaged barrier function, there are increased inflammatory responses as the skin tries to protect itself.
You can also use the pinch test to assess skin hydration. Gently pinch the skin on the cheek; if you see fine lines appear and the skin takes longer to return to normal position, it is likely dehydrated.
When skincare professionals look at the skin with a magnifying lamp, the skin has a fine, cracked, mesh-like pattern across its surface.
How Dehydration Affects Different Skin Types
Dehydration can affect all skin types (dry, oily, and combination) and will manifest differently depending on the skin type. The signs listed above will be present on the skin combined with specific characteristics relating to how it affects a particular skin type.
Combination and oily skins produce more sebum to compensate for the lack of moisture in the skin. Because poor hydration impairs desquamation, it can lead to a build of corneocytes, sebum, and debris on the skin and in the pores. As a result, these skin types are prone to developing blackheads, which are difficult to remove without treating the skin’s dehydration.
When it comes to dry skin, it is important to distinguish if the skin is dry or if it is dehydrated dry skin.
Dry skin is a skin type caused by the skin being lipid (oil) deficient, where it does not produce enough natural oils to keep it healthy and resilient.
Dehydrated dry skin occurs when the skin is water and lipid deficient.
It’s important to distinguish between the two, because while they share some similarities, they need different approaches when treating them.
So, how do you recognize the difference between the two? Use this table to help you:
|
Dry Skin |
Dehydrated Dry Skin |
Problem |
Lacks oil (lipids) |
Lacks water and oil (hydration and lipids) |
Texture & Feel |
Skin feels rough, flaky, and tight most of the time tight
|
Skin feels tight, uneven, and has a network of fine dehydration lines present. There is often an uncomfortable "pulling" sensation, especially after cleansing.
|
Appearance |
Dull, may have visible cracks or peeling More prone to fine lines and premature aging because of the lack of natural moisture retention.
|
Dull, but may also look tired or lifeless |
Barrier Function |
Naturally weaker due to lack of protective lipids
|
Further weakened due to water loss |
Sensitivity |
Prone to irritation, especially in harsh weather May have redness or irritation due to insufficient protective oils.
|
More reactive, may sting or feel uncomfortable Can become more sensitive, reactive, or prone to irritation. |
Response to Moisturizer |
Needs richer creams to replenish oils Always dry, regardless of hydration levels
|
Skin absorbs moisturizer quickly but still feels thirsty
|
Cause |
Genetics, aging, lipid barrier dysfunction |
Over-cleansing, harsh products, weather and environmental conditions, and lifestyle factors
|
Treatment Goals |
Replenish lipids with ceramides, squalane, and oils |
Restore hydration with humectants like hyaluronic acid and glycerin, followed by occlusives
|
Permanence |
A long-term skin type |
A temporary skin condition that can be reversed. |
The good news is that dehydration is a temporary skin condition, no matter your skin type. With the right products and skincare routine, you can restore hydration and regain your skin’s balance.
Seasonal changes affect hydration in all skin types, including normal, well-balanced skin. The skin's natural hydration processes need time to adjust to shifts in humidity and temperature. Indoor heating and cooling systems make this even more challenging by creating artificially dry environments.
Your skin is always reacting to what’s happening around you and inside your body. Since hydration is key to its health, your skin’s moisture levels naturally change as it adjusts to different conditions.
The Connection Between Hydration and Other Skin Concerns
Skin hydration affects most skin conditions and concerns. It can both cause and aggravate these conditions. This means addressing hydration plays an important role in helping to treat and improve these conditions, too.
Acne and Breakouts:
Many people don’t realize that dehydration can worsen acne.
Because lack of hydration compromises the skin barrier, it triggers an increase in sebum production to help protect it. This excess sebum, combined with the build-up of corneocytes from impaired desquamation, creates an ideal environment for acne causing bacteria -- Cutibacterium acnes (C. acne), previously known as Propionibacterium acnes (P. acne)-- to multiply.
The inflammation resulting from barrier dysfunction exacerbates existing acne lesions and prolongs their healing time.
Studies 2,3 have shown that properly hydrated skin actually responds better to traditional acne treatments, with reduced irritation and improved efficacy.
Aging and Wrinkle Formation:
Chronic dehydration accelerates both intrinsic and extrinsic aging.
Well-hydrated skin is more resilient against environmental stressors like UV radiation, pollution and harsh weather, which are factors that contribute to premature aging.
When the dermis has enough water, it provides the optimal environment for fibroblasts to synthesize collagen and elastin efficiently and keep the skin firm and supple.
Without adequate hydration, these cells produce poor quality proteins in lower quantities, leading to fine lines and deeper wrinkles.
Also, hyaluronic acid—the skin's natural "plumping" molecule—relies on proper hydration to maintain its volume-enhancing properties, helping the skin stay smoother and more youthful.
As you age, the skin’s ability to retain moisture decreases. This means it needs extra support to maintain healthy hydration levels to maintain both its health, firmness and elasticity while slowing down the formation of wrinkles.
Pigmentation Disorders:
Hydration plays a crucial role in regulating melanin production through several interconnected processes.
Dehydration causes the skin to protect itself, increasing inflammation and raising the risk of post-inflammatory hyperpigmentation.
A weakened skin barrier also allows more UV radiation to penetrate, stimulating melanocytes and boosting pigment production.
Research shows that well-hydrated skin not only promotes a more even melanin distribution but also enhances the effects of brightening ingredients by improving their absorption and minimizing irritation.
Sensitivity and Reactive Skin:
Hydration plays a key role in regulating skin sensitivity. When the skin is dehydrated, its permeability increases, allowing irritants and allergens to penetrate more easily and triggering inflammation.
Neurosensory receptors in the skin also become hypersensitive in a dehydrated environment, which is why people with chronically dehydrated skin often experience stinging or burning—even from products they once tolerated.
Clinical studies 4,5 consistently show that restoring optimal hydration reduces both the physical and perceived signs of skin sensitivity.
Barrier Disorders:
Conditions like eczema, psoriasis, and rosacea stem from barrier dysfunction, with dehydration acting as both trigger and consequence.
For the skin barrier to repair itself, it needs proper lipid synthesis and enzyme activity—both of which depend on adequate hydration. A lack of moisture disrupts these processes, weakening the barrier further and worsening the condition.
Recent research highlights that many genetic mutations linked to these skin conditions affect proteins responsible for water retention and transport within the skin, reinforcing hydration’s essential role in maintaining skin barrier integrity.
Microbiome Balance:
Many people don’t realize that the skin has a diverse community of microorganisms that live on its surface. These microorganisms (also called microbes) include bacteria, fungi, and even viruses, and they are invisible to the naked eye.
You can think of them as an ecosystem or microbiome on your skin.
These microbes play an essential role in maintaining skin health by supporting the barrier function, regulating inflammation, and protecting you against harmful pathogens.
A balanced microbiome where communities of helpful microbes are thriving helps keep the skin hydrated, resilient, and less prone to infections and conditions like acne, eczema, and sensitivity.

Internal changes, harsh skincare products, antibiotics, or environmental factors disrupt the microbiome, and lead to imbalances that weaken your skin barrier and contribute to irritation or breakouts. Supporting the microbiome with gentle skincare and prebiotic or probiotic ingredients can help maintain a healthy, radiant complexion.
Emerging research shows that skin hydration influences the balance of the microbiome.
Dehydrated environments cause certain microbial species to thrive over others and disrupt the delicate balance required for skin health.
Studies 6 show that restoring optimal hydration helps normalize microbiome diversity, which improves various skin conditions through reduced pathogen colonization and enhanced barrier function.
Understanding these connections leads to more effective skincare strategies. Instead of treating hydration as an isolated issue, advanced treatments incorporate it into solutions for acne, aging, pigmentation, and sensitivity.
Understanding Hydrating Ingredients
Humectants, Emollients and Occlusives: What Are They and Why Do They Matter?
As our understanding of skin hydration developed, we’ve learned that hydrating the skin is more than just applying moisture—it’s about using the right ingredients in the right way.
To get the most out of your skincare routine, it’s important to know what the skin needs to stay hydrated and how different ingredients work together to support moisture balance.
We classify hydrating ingredients into three major categories based on how they interact with the skin:
- Humectants – Draw moisture into the skin.
- Emollients – Smooth and soften the skin by replenishing lipids.
- Occlusives – Form a protective barrier to prevent moisture loss.
Each category plays a unique role in maintaining hydration, and understanding how they work together can help you create an effective, well-balanced skincare routine.
Let’s explore them in more detail.
Humectants: Water-Attracting Agents
Function: Humectants draw water from the atmosphere and deeper skin layers into the stratum corneum and bind it to the skin’s surface.
Mechanism: They contain hydroxyl groups that form hydrogen bonds with water molecules, allowing them to bind and retain moisture.
Examples: Hyaluronic acid, glycerin, panthenol, aloe vera, propanediol, propylene glycol, urea, alpha hydroxy acids (AHAs), honey, and sorbitol.
Benefits: Provide immediate hydration, help plump and hydrate the skin by increasing its water content and support enzymatic processes.
Limitations: Because humectants draw water from the lower levels of the skin to the stratum corneum, they can potentially increase water loss from the skin in very dry environments (low humidity levels) if they are not used with occlusives.
Best For: Helping to plump and hydrate the skin by increasing its water content.
Emollients: Smoothing and Softening Agents
Function: Fill in gaps between skin cells to create a smooth surface and soft texture.
Mechanism: Contain lipid-based ingredients that integrate with the skin’s natural barrier and soften the surface by filling spaces between corneocytes.
Examples: Squalane, fatty acids, ceramides, cholesterol, plant oils, esters.
Benefits: Smooths and softens the skin, prevents roughness, supports barrier repair, and enhances skin comfort.
Limitations: Primarily improves skin texture rather than directly increasing water content.
Best For: Moisture retention, improving barrier function, and smoothing and softening the skin.
Occlusives: Barrier-Forming Agents
Function: Create a hydrophobic film on the skin’s surface to prevent trans epidermal water loss (TEWL).
Mechanism: Form a physical barrier that water molecules cannot easily penetrate.
Examples: Petrolatum, dimethicone, beeswax, lanolin, certain vegetable butters.
Benefits: Locks in moisture, protects against dehydration, and significant barrier support.
Limitations: Can feel heavy or greasy; may trap heat or sweat.
Best For: Very dry or compromised skin; extreme weather protection. They seal moisture into the skin.
While humectants, emollients, and occlusives are essential for hydration, barrier repairing ingredients and aquaporin boosting ingredients play a vital support role in ensuring hydration is retained and effectively distributed within the skin.
This table makes it easy to compare the three categories of hydrating ingredients:
Ingredient Category: |
Humectants: (Water attracting) |
Emollients: (Smoothing and softening) |
Occlusives: (Barrier forming) |
Function: |
Draw water from the atmosphere and deeper skin layers into the stratum corneum |
Fill in gaps between skin cells to create a smooth surface and soft texture |
Create a hydrophobic film on the skin’s surface to prevent trans epidermal water loss (TEWL) |
Mechanism: |
Contain hydroxyl groups that form hydrogen bonds with water molecules, allowing them to bind and retain moisture |
Contain lipid-based ingredients that integrate with the skin’s natural barrier and soften the surface by filling spaces between corneocytes |
Form a physical barrier that water molecules cannot easily penetrate |
Examples: |
Hyaluronic acid, glycerin, panthenol, sodium PCA, urea urea, AHAs, honey, sorbitol |
Squalane, fatty acids, ceramides, cholesterol, plant oils, jojoba oil, esters |
Dimethicone, beeswax, lanolin, vegetable butters |
Benefit: |
Immediate hydration, plumps and hydrates skin, supports enzymatic processes |
Smooths and softens skin, prevents roughness, supports barrier repair, enhances comfort |
Locks in moisture, protects against dehydration, provides significant barrier support |
Limitations: |
Can increase water loss in very dry environments if not paired with occlusives |
Primarily improves skin texture rather than increasing water content |
Can feel heavy or greasy; may trap heat or sweat |
Recommendations: |
Helping to plump and hydrate the skin by increasing its water content.
|
Moisture retention, improving barrier function, and smoothing and softening the skin.
|
Very dry or compromised skin; nighttime use; extreme weather protection
|
While humectants, emollients, and occlusives are the primary ingredients for skin hydration, two other categories also play a crucial role in maintaining moisture balance.
Barrier-repairing and aquaporin-boosting ingredients help strengthen the skin’s protective function and enhance water distribution, ensuring long-lasting hydration.
For optimal skin hydration and moisture retention, a well-rounded skincare routine should ideally incorporate all five of these categories.
Barrier Repairing Ingredients: Strengthening Agents
Function: Actively restore the skin’s natural lipid composition to improve long-term hydration and resilience.
Mechanism: Combine with the skin’s lipid matrix to rebuild and strengthen barrier function.
Examples: Ceramides, cholesterol, and free fatty acids, niacinamide.
Benefits: Restore and strengthen the skin barrier by replenishing missing lipids, reduce trans epidermal water loss (TEWL) by reinforcing the lipid structure.
Limitations: While they reduce trans epidermal water loss, they do not actively draw water into the skin like humectants. Without enough water present, their effects on hydration are limited.
Best For: Strengthening a weakened skin barrier, long-term moisture retention and supporting deep hydration treatments.
Aquaporin Boosting Ingredients: Water Distribution Agents
Function: Enhance water movement by improving the skin’s ability to transport and retain moisture between cells for optimal hydration distribution.
Mechanism: Stimulate keratinocytes to produce aquaporin proteins, facilitating the transfer of water and glycerol from the dermis to the epidermis.
Examples: Niacinamide, glycerin, urea, resveratrol, ginseng extract, trehalose, betaine, lactic acid.
Benefits: Promotes deep, even hydration throughout the skin, enhances the effectiveness of other hydrating ingredients, reduces trans epidermal water loss (TEWL), and supports the skin barrier.
Limitations: Improves water transport but does not generate or retain moisture on its own, requiring humectants, emollients, or occlusives for optimal hydration.
Best For: Ensuring efficient moisture distribution between deeper and outer skin layers to maintain balanced hydration.
Multifunctional Ingredients:
If you’re wondering if some ingredients can span multiple categories, and offer combined benefits, the answer is yes. Here are some examples:
- Ceramides function as both emollients and mild occlusives.
- Shea butter provides emollient effects with moderate occlusive properties
- Fatty acids can act as both barrier repair agents and emollients
How to Use Humectants, Emollients, Occlusives & Supporting Ingredients for Maximum Hydration
A skincare routine focused on hydration should include ingredients from all three categories. The best approach is to apply them in a strategic order:
- Humectants first, to attract and bind water.
- Emollients next, to smooth and support the skin barrier.
- Occlusives last, to lock in moisture and prevent water loss.
This layering method works with the skin’s natural hydration system by promoting moisture absorption, retention, and protection. A well-structured routine should incorporate all these categories along with the supporting ingredients to enhance hydration effectively. Here’s how:
1. Start with Humectants (Hydration Boosters)
Why? Humectants draw water into the skin, plumping and hydrating it.
When should you apply them? Right after cleansing, on damp skin, to maximize water absorption.
Ingredient examples: Hyaluronic acid, glycerin, urea, panthenol, aloe vera.
Best ways to apply humectants:
- Apply a hydrating toner, mist, or essence first.
- Follow with a hydrating serum containing hyaluronic acid or glycerin.
- Seal the hydration quickly with the next step to avoid evaporation.
📌 Pro Tip: Layer multiple humectants, such as hyaluronic acid + glycerin for enhanced moisture-binding capacity.
2. Add Barrier-Repairing Ingredients (Long-Term Moisture Support)
Why? These reinforce the skin’s natural lipid barrier, preventing dehydration over time.
When should you apply them? After humectants, in a serum or lightweight lotion.
Ingredient examples: Ceramides, cholesterol, fatty acids, niacinamide.
Best ways to apply barrier repairing ingredients:
- Use a barrier-supporting serum with an ingredient like niacinamide or a moisturizer with ceramides.
- If using an occlusive moisturizer, apply barrier strengthening products before occlusives.
📌 Pro Tip: Look for ceramide formulas with cholesterol and fatty acids in a 3:1:1 ratio for optimal skin barrier repair. (In other words, 3 parts ceramides: 1 part cholesterol: 1-part fatty acids)
3. Apply Emollients (Skin Softening & Smoothing)
Why? Emollients fill gaps between skin cells, improving texture and suppleness.
When should you apply them? In your moisturizer, after humectants and barrier-repairing ingredients.
Ingredient examples: Squalane, plant oils, esters, fatty alcohols.
Best way to apply them:
- Choose a moisturizer rich in emollients if your skin feels tight or rough.
- If your skin is very dry, use a face oil before applying an occlusive.
📌Pro Tip: Squalane is a non-greasy, fast-absorbing emollient that works well for all skin types.
4. Lock Everything in with Occlusives (Moisture Sealers)
Why? Occlusives prevent trans-epidermal water loss (TEWL) and keep hydration locked in.
When should you apply them? They are the last step of your routine (except for sunscreen in the morning).
Ingredient examples: Shea butter, beeswax, lanolin, dimethicone,
Best way to apply them:
- Use an occlusive moisturizer, for example, one with shea butter or beeswax if your skin is prone to dryness or you live in a harsh climate.
📌Pro Tip: Occlusives work best in dry climates but may feel too heavy in humid conditions.
5. Bonus Step: Use Aquaporin-Boosting Ingredients for Enhanced Water Flow
Why? They help transport water molecules between skin cells, ensuring deeper hydration.
When should you apply them? It will depend on the products you are using and the ingredients they contain. You will apply them in step 1, 2, or 3.
Ingredient examples: Niacinamide, glycerin, urea, resveratrol, ginseng extract.
Best way to apply them:
- When you apply serums, essences, or lightweight moisturizers.
📌Pro Tip: Niacinamide is an excellent multitasker—it boosts aquaporins, strengthens the skin barrier, and reduces inflammation.
Expert Tips on Layering for Different Skin Types
Each skin type has different needs when it comes to a hydrating routine. So, it makes sense that you will adjust the products you use and the way you layer them to address these needs. This is what to focus on for each skin type:
Oily Skin:
Focus on humectants and lightweight emollients like squalane.
You need lightweight, fast-absorbing layers that strengthen the barrier while controlling excess oil.
Choose products that are gel based or water-based formulations, like mists, serums or lightweight moisturisers.
Avoid heavy occlusives, unless the skin is showing signs of dehydration in a dry climate or winter. Your routine should include these types of formulations:
- Barrier Strengthening: Lightweight serum or mists
- Humectants: Hydrating serums or essences
- Light Emollients: Lightweight emulsions, moisturisers, lotions or gel creams
- Light Occlusives: Light Moisturizers or gel-based occlusives if needed
Combination Skin:
The goal for combination skin is to balance hydration across different areas of the face to provide enough moisture to dry areas while keeping the oilier zones from becoming congested.
The best approach is lightweight, layered hydration with targeted application where needed.
Like oily skin, it needs humectants and lightweight emollients. It will also benefit from barrier repairing and aquaporin boosting ingredients.
Use different moisturizers for different areas if needed (gel for oily zones, cream for dry areas).
Adjust occlusives seasonally by using richer occlusives in winter on dry areas, then switch to lighter formulations in summer.
This approach ensures that both dry and oily areas stay hydrated without congestion, creating a balanced, healthy skin barrier.
For a combination skin, use these types of formulations in your routine:
- Barrier Strengthening: Lightweight serum or mists
- Humectants: Hydrating serums or essences
- Emollients: Lightweight emulsions, or creams, layer if needed
- Occlusives: Light to medium weight occlusives with targeted application
Dry Skin:
For dry skin, you need to maximize moisture absorption, retention, and protection while reinforcing the skin barrier.
When dry, dehydrated skin lacks water and lipids, the focus should be on deep hydration, replenishing lipids, and preventing moisture loss.
Use all four layers, focussing on emollients (ceramides, fatty acids) and occlusives. Dry skins also need barrier strengthening and aquaporin boosting ingredients in the serums and moisturizers you use.
Apply multiple layers of hydrating products rather than relying on one heavy moisturizer and layer hydrating products on damp skin to improve absorption.
This routine mimics the skin’s natural moisturizing system and ensures long-lasting hydration, resilience, and comfort for dry skin.
Dry skin needs these types of formulations:
- Barrier Strengthening: Serums or mists
- Humectants: Hydrating serums or essences, apply in multiple thin layers for deeper penetration
- Emollients: Rich moisturisers, balms or creams
- Occlusives: Heavy creams, balms, or facial oils, especially at night
Sensitive Skin:
For sensitive skin focus on lightweight, soothing hydration and strengthening the barrier without overwhelming the skin.
Choose barrier-repairing ingredients (ceramides, niacinamide) and avoid heavy occlusives if prone to irritation.
Maximize hydration and minimize irritation to ensure moisture absorption, retention, and sealing for long-lasting comfort.
A sensitive skin routine should include these types of formulations:
- Barrier Strengthening: Lightweight serums or mists
- Humectants: Hydrating serums or essences
- Emollients: Light creams or lotions
- Light to medium weight occlusives: Gentle moisturizers or oils
Star Hydrating Ingredients: Power Players From Hyaluronic Acid to Exosomes
Hyaluronic Acid
For some time now, hyaluronic acid has been the darling of the skincare industry, and there are many reasons why it has earned this reputation.
Knowing it’s in the products you’re using, probably gives you confidence you’re using something good for your skin. But not all hyaluronic acid is the same. To choose and use your products wisely, it helps to know exactly how it helps your skin and what to look for in formulations so you get the most from this active ingredient.
What It Is and How It Works?
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan (GAG) found throughout your body's connective tissues, with particularly high concentrations in the skin, especially the dermis.
This remarkable molecule is often called a "moisture magnet" because of its extraordinary capacity to bind water—up to 1,000 times its weight. It plays important roles not just in how the skin looks, but also how it functions.
In the skin, HA fills the spaces between collagen and elastin fibers in the dermis, providing structural support while maintaining optimal hydration. It also plays vital roles in:
Hydration and Water Retention
By now you’re familiar with HA’s reputation as a powerful humectant. This remarkable capacity keeps both the epidermis and dermis well-hydrated, which:
- Maintains skin elasticity and suppleness
- Reduces the appearance of fine lines and dryness
- Supports a plump, smooth texture
Skin Barrier Support
By maintaining hydration, HA indirectly strengthens the skin’s lipid barrier. A healthy barrier helps protect against trans-epidermal water loss (TEWL) and environmental stressors. In doing so, HA plays a role in preventing irritation, sensitivity, and inflammation.
Structural Support in the Dermis
Hyaluronic acid is a key component of the dermal extracellular matrix, which surrounds skin cells like fibroblasts. Within this matrix, HA:
- Provides gel-like cushion that supports collagen and elastin
- Helps maintain the structure and integrity of the dermal scaffold
- Assists cell movement and nutrient exchange
Wound Healing and Cell Signalling
In response to injury or inflammation, HA becomes actively involved in the repair process. It:
- Triggers immune cells to manage inflammation and release growth factors that promote healing.
- Attracts fibroblasts and keratinocytes to the wound site to support tissue regeneration.
- Stimulates the formation of new blood vessels (angiogenesis), delivering oxygen and nutrients while removing waste
- Encourages cellular movement and renewal, accelerating wound repair.
Why Do You Need to Apply Hyaluronic Acid to Your Skin?
As we age, the amount of natural hyaluronic acid (HA) in our skin decreases. By the time we reach our 40s, we have less than half as much as we did in our 20s.
This decline leads to visible signs of aging, like loss of volume, dryness, and a weaker skin barrier.
When you apply HA to your skin, it draws moisture from the air and from deeper layers of the skin (the dermis) to hydrate the surface. This surface hydration also supports its ongoing roles in the dermis, like maintaining structure, aiding cell communication, and supporting the skin barrier.
Weight Makes All the Difference: Molecular Weights and Their Benefits
Today, there are so many products that contain hyaluronic acid, and most skincare ranges offer hyaluronic acid products. But not all hyaluronic acid is created equal.
HA has different weights which are determined by the molecule’s size (and measured in units called Daltons- kDA) and this affects the way it interacts with the skin.
Understanding this helps you to make better decisions about the products you are choosing and using.
Here is how the different weights affect the skin:
High Molecular Weight HA (1,000-1,800 kDa):
- Penetrates the upper layers of the stratum corneum
- Provides immediate surface hydration and smoothing
- Reduces trans-epidermal water loss
- Temporarily plumps fine lines
- Limited penetration beyond the stratum corneum
Medium Molecular Weight HA (100-1,000 kDa):
- Penetrates slightly deeper to the upper layers of the stratum granulosum
- Provides sustained hydration in the epidermis
- Helps calm mild inflammation
- Aids in repairing and strengthening the skin barrier
Low Molecular Weight HA (5-100 kDa):
- Reaches deeper layers of the epidermis down to the stratum spinosum
- Encourages the skin to produce more of its own hyaluronic acid
- Helps reduce inflammation more effectively
- Activates cell receptors that help with skin healing
- May boost the activity of genes involved in healthy skin cell development
Ultra-Low Molecular Weight HA (<5 kDa):
- Has the deepest penetration and may reach as deep as the stratum germinativum (basal layer)
- Most effective at boosting the skin’s own hyaluronic acid production
- Influences deeper dermal processes
- Likely has the strongest ability to send signals that guide cell behavior
Advanced skincare formulas often use a spectrum of the molecular sizes to hydrate multiple layers of the skin. This “multi-weight” approach gives instant surface benefits while also supporting deeper, longer-lasting improvements over time.

Optimal Concentration and Formulation
How well hyaluronic acid works depends not just on its molecular weight, but also on concentration and formulation factors:
Concentration: Hyaluronic acid works best at concentrations between 1% and 2% in leave-on products. Higher concentrations don’t always improve results and may make the texture feel sticky without offering extra benefits.
Delivery Systems: Formulation techniques that improve how hyaluronic acid is delivered can enhance its performance by making it more stable and allowing it to stay active on the skin longer. These techniques include liposomal delivery, encapsulation, and cross-linking.
Support Ingredients: HA works best when it’s formulated with:
- Other humectants, like glycerin, that help create a moisture gradient that boosts HA’s ability to bind water
- Ingredients that support the skin barrier to prevent moisture loss
- Penetration enhancers, like those mentioned above in delivery systems, for deeper delivery when needed
- Antioxidants that protect HA from breaking down
Formulation Type: While hyaluronic acid appears in everything from cleansers to creams, it delivers maximum benefits in leave-on products like serums.
Skin Types and Concerns That Benefit Most from Hyaluronic Acid
While most skin types benefit from well-formulated hyaluronic acid, some conditions see noticeable improvements with it:
Dehydrated but oily skin: Hyaluronic acid delivers lightweight, oil-free hydration without increasing oil production.
Post-procedure skin: Helps speed up healing and reduce irritation after treatments like microdermabrasion or laser therapy.
Mature skin: Replenishes moisture and supports skin that produces less natural HA with age.
Exposure to environmental stress: Helps protect the skin from moisture loss caused by pollution, dry air, and harsh weather.
Weakened skin barrier: Aids in recovery for conditions like eczema, rosacea, or irritation from retinoids.
Sensitive skin: Provides gentle hydration with a low risk of causing further sensitivity or reactions.
To get the most out of HA products, apply them to damp skin. In very dry climates, it is important to use hyaluronic acid with an occlusive. Using it without an occlusive may actually cause water to evaporate from the skin more quickly.
Glycerin
How Does Glycerin Support Skin Hydration and Barrier Health?
Glycerin (also called glycerol) has exceptional water-binding properties.
As one of skincare's oldest and most reliable humectants, it has many essential benefits for the skin:
- Draws water from the atmosphere and deeper skin layers into the stratum corneum.
- Integrates with the intercellular lipid structure of the epidermis to improve barrier function.
- Affects the activity of enzymes involved in normal desquamation to assist with desquamation and skin renewal.
- Acts as a "osmoprotectant," protecting the skin’s cells from dehydration and the stress it causes to the skin.
- Helps maintain the skin’s pH balance
What's remarkable about glycerin is its ability to adapt based on environmental conditions. In high humidity, it attracts external moisture to the skin; in low humidity, it helps retain the skin's existing moisture content.
Glycerin vs. Hyaluronic Acid : How Do They Compare?
While both glycerin and hyaluronic acid function as humectants, they differ in several important ways:
Molecular Structure and Size:
- Glycerin is a small, simple molecule that penetrates skin relatively easily
- HA is a complex, high-molecular-weight polymer with varying penetration ability based on size
Water-Binding Capacity:
- Glycerin binds approximately 3 times its weight in water
- Hyaluronic acid can bind up to 1,000 times its weight in water
Duration of Effect:
- Glycerin's effects are shorter-lived but more immediate
- Hyaluronic acid (particularly higher molecular weights) provides longer-lasting hydration
Sensory Properties:
- Glycerin can feel sticky at high concentrations
- Hyaluronic acid typically feels less tacky and more elegant in well-formulated products
Additional Benefits:
- Glycerin offers pronounced antimicrobial properties
- Hyaluronic acid provides more significant anti-inflammatory and wound-healing benefits
Environmental Resilience:
- Glycerin performs relatively consistently across humidity levels
- Hyaluronic acid may be less effective in extremely dry environments without occlusive agents
These differences do not make one ingredient better than the other. Instead, professional formulations often leverage both ingredients, to make the most of their complementary properties.
Comparing Humectants: Glycerin vs.Hyaluronic Acid
Property: |
Glycerin: |
Hyaluronic Acid: |
Molecular Size & Structure:
|
Small, simple molecule; penetrates easily |
Large polymer: penetration depends on molecular weight |
Water-Binding Capacity:
|
Binds 3 times its weight in water |
Can bind up to 1,000 times its weight in water |
Hydration Longevity:
|
Shorter-lived but immediate hydration |
Longer-lasting hydration, especially with higher molecular weights |
Sensory Properties:
|
Can feel sticky or tacky at high concentrations
|
Typically feels smooth, less tacky in well-formulated products |
Additional benefits: |
Antimicrobial properties |
Anti-inflammatory and wound-healing benefits
|
Environmental Resilience:
|
Performs well across different humidity levels |
May be less effective in very dry air without occlusives |
Which Skin Types and Concerns Benefit Most from Glycerin?
Dry skin: Helps attract and retain moisture, reducing tightness and flaking.
Sensitive skin: Soothes and hydrates without irritation. It is gentle and non-sensitizing.
Oily and acne-prone skin: Lightweight and non-comedogenic; hydrates without congesting the pores.
Combination skin: Balances moisture across different zones of the face.
Aging skin: Helps maintain hydration, plumpness, and barrier function.
Sensitive skin: Glycerin supports most skin concerns and is particularly beneficial in helping compromised barrier function, redness, irritation, and sensitivity.
What Are The Best Skincare Formulations for Glycerin?
- Serums and Essences (especially water-based)
- Hydrating Toners or Mists
- Moisturisers and Creams
- Cleansers (to reduce dryness after cleansing)
- Sheet Masks
- Hand and Body Lotions
Smart Ingredient Allies: What Works Best with Glycerin?
Glycerin has excellent synergy with many other skincare ingredients:
Ceramides and Fatty Acids: Glycerin enhances the effectiveness of these barrier-repairing ingredients by helping to organize their structure within the stratum corneum.
Alpha and Beta Hydroxy Acids (AHAs & BHAs): Glycerin helps reduce irritation from exfoliating acids without affecting how well they work.
Retinoids: By improving barrier function and hydration, glycerin reduces retinoid-induced dryness and irritation.
Antioxidants: Glycerin creates an ideal hydrating environment that optimizes the function of water-soluble antioxidants.
Niacinamide: This combination provides superior barrier repair while addressing multiple skin concerns simultaneously.
Panthenol (Vitamin B5): Together with glycerin, panthenol creates comprehensive skin-soothing and barrier-supporting effects.
Natural Moisturizing Factors (NMFs): Glycerin works synergistically with amino acids, urea, and lactic acid to mimic the skin's natural moisturizing system.
Glycerin works best when used in several steps of your skincare routine (like toners, serums, and moisturizers) when each product is paired with ingredients that boost its benefits.
Niacinamide
Niacinamide (also known as vitamin B3) is a versatile, water-soluble active ingredient. It improves skin hydration, strengthens the barrier function, and addresses a wide range of concerns like uneven tone, enlarged pores, and inflammation.
How Does Niacinamide Support Skin Hydration and Barrier Health?
When it comes to skin hydration, niacinamide:
Boosts Natural Moisturizing Factors (NMFs): Niacinamide increases the production of NMF components in the skin, such as ceramides, free fatty acids, and cholesterol. These help skin hold on to water more effectively.
Reduces Trans-epidermal Water Loss (TEWL): By strengthening the skin’s barrier, it limits water escaping from the surface, to improve skin hydration.
Balances Sebum Production: It helps regulate sebum levels, which supports hydration and barrier function without making skin oily.
It also plays an important role in strengthening the skin’s barrier:
Stimulates Ceramide Synthesis: It restores the lipid barrier and improves the skin’s resilience.
Strengthens the Stratum Corneum: Reinforces the outermost layer of the epidermis, making skin more resistant and less reactive to irritants.
Anti-Inflammatory Properties: Calms redness and irritation, especially in compromised or inflamed skin.
Which Skin Types and Concerns That Benefit Most from Niacinamide?
Oily and acne-prone skin: Regulates sebum secretions, reduces inflammation and post-breakout marks.
Dry or dehydrated skin: Supports hydration from within by restoring and strengthening the barrier.
Sensitive or rosacea-prone skin: Calms and soothes the skin while strengthening the skin’s barrier and making it more resilient.
Aging skin: Improves elasticity, barrier function, and skin tone.
Hyperpigmentation: Reduces the appearance of dark marks and uneven tone.
What Are The Best Skincare Formulations for Niacinamide?
- Serums: Lightweight serums will penetrate deeply; especially when paired with other actives.
- Moisturizers: Combined with emollients and occlusives to lock in the hydrating effects.
- Toners or Mists: Help prepare the skin while delivering a gentle dose of hydration.
- Cleansers: Mild daily use cleansers for sensitive or acne-prone skin.
Smart Ingredient Allies: What Works Best with Niacinamide?
Ceramides: Together they amplify barrier-repair effects.
Glycerin: Boosts hydration and smooths skin texture.
Hyaluronic Acid: Adds surface hydration while niacinamide supports deeper water retention.
Panthenol: They work synergistically to soothe inflammation and support stressed skin.
Allantoin: Enhances calming and barrier-soothing effects.
Peptides
Peptides are amino acids that act as messengers in skincare, that stimulate skin cells to perform functions like collagen production, barrier repair, and hydration. In skincare products, they help improve skin firmness, smoothness, and resilience over time.
How Do Peptides Support Skin Hydration and Barrier Health?
Peptides support hydration and barrier function directly and indirectly. Directly, they signal the skin to produce essential structural proteins and lipids, while indirectly they enhance the skin’s own regenerative processes. Here's how:
Stimulate natural moisturizing factors (NMFs): Certain peptides encourage the production of NMF components, improving moisture retention in the stratum corneum.
Enhance lipid synthesis: Signal peptides can stimulate the production of ceramides, cholesterol, and fatty acids—key elements in maintaining a healthy skin barrier.
Support collagen and elastin synthesis: While not hydrating themselves, increased collagen leads to a firmer, smoother texture, and reduces TEWL (trans-epidermal water loss).
Improve cell communication: Peptides act as messengers, helping the skin respond to environmental stress and damage more efficiently.
Which Skin Types and Concerns Benefit Most from Peptides?
Dry and dehydrated skin: Boost moisture retention and help rebuild a compromised barrier.
Sensitive or damaged skin: Reduce inflammation, soothe the skin while repairing and strengthening the barrier function.
Aging skin: They promote firmness, elasticity, and surface hydration by encouraging collagen and elastin synthesis.
Post treatment skin: Because peptides hydrate the skin and speed skin repair and regeneration, they are ideal for recovery after peels, microneedling, or laser treatments.
What Are the Best Skincare Formulations for Peptides?
Peptides are very versatile and are most effective in:
- Serums: Most common delivery system; they allow high concentration and targeted delivery.
- Moisturizers: Combine peptides with humectants and occlusives for barrier repair and hydration.
- Eye creams: Excellent for smoothing fine lines and improving elasticity in delicate areas.
- Post-procedure products: They help to accelerate healing and hydration after medical aesthetic treatments.
Smart Ingredient Allies: What Works Best with Peptides?
Hyaluronic acid: Enhances surface hydration, allowing peptides to work in a plump, moist environment.
Ceramides: Strengthen the barrier alongside peptide-triggered lipid synthesis.
Niacinamide: Supports peptide function with anti-inflammatory and barrier-repair properties.
Panthenol: Soothes and hydrates, improving skin comfort while peptides rebuild.
Antioxidants: Protect peptides and support collagen stimulation.
Growth Factors
Growth factors are powerful, active proteins that play a central role in skin regeneration, repair, and hydration. Using them in skincare products they help to support these processes topically on the skin.
While they’re not categorized as humectants or occlusives, their indirect effects on hydration and skin barrier repair make them stand out ingredients in advanced skincare that are worth mentioning.
How Do Growth Factors Support Skin Hydration and Barrier Repair?
Stimulate Cellular Regeneration: Growth factors encourage the production of new skin cells, collagen, and elastin, which strengthen the skin barrier and enhance moisture retention.
Improve Barrier Function: By supporting the skin’s natural renewal processes, growth factors contribute to healthier, more resilient skin that retains hydration.
Promote Wound Healing: They accelerate repair in damaged or compromised skin, which is important in conditions like eczema or post medical aesthetic treatments recovery.
Increase Natural Moisturizing Factors (NMFs): Some growth factors indirectly boost the production of substances like hyaluronic acid, improving skin hydration from within.
Which Skin Types and Concerns Benefit Most from Growth Factors?
Aging skin: Enhances elasticity, hydration, and firmness.
Dry and dehydrated skin: Supports long-term moisture retention.
Sensitive and compromised skin: Helps repair barrier function and calms inflammation.
Post aesthetic treatment skin: Ideal after microneedling, lasers, or peels to speed up healing.
What are the Best Skincare Formulations for Growth Factors?
Serums: Ideal for delivering growth factors into the skin’s deeper layers.
Post-procedure products - masks, serum and ampoules: To accelerate healing and soothe redness and inflammation.
High-performance creams and eye treatments: For targeting aging and thinning skin.
Smart Ingredient Allies: What Works Best with Growth Factors?
Hyaluronic Acid: Boosts hydration and improves growth factor delivery into the skin.
Niacinamide: Strengthens barrier function and improves skin tone.
Peptides: Complement growth factors in stimulating repair and collagen production.
Ceramides: Reinforce the skin barrier while growth factors regenerate skin.
Antioxidants: Protect newly formed skin structures from oxidative stress.
Exosomes
Exosomes are like tiny delivery packages filled with powerful bioactive materials, like growth factors, peptides, lipids, amino acids, and more. These little bubbles (called vesicles) deliver their contents directly into skin cells.
Once inside, the bioactive compounds communicate with the cell, triggering key biological processes. For example, if the exosomes carry growth factors, they can help stimulate collagen production or support cell renewal.
What makes exosomes so unique in skincare is their ability to speak the skin’s language. They don’t just sit on the surface, they actively encourage repair, hydration, and rejuvenation from within.
Unlike single-ingredient actives, exosomes offer a multi-functional approach by hydrating, soothing, strengthening, and restoring all at once. They can carry a mix of compounds, and what they contain depends on their source. In skincare, they’re usually derived from plant, adipose, or mesenchymal stem cells—chosen for their exceptional regenerative benefits.

How Do Exosomes Support Skin Hydration and Barrier Health?
As nano-sized vesicles, these cell-to-cell messengers deliver lipids, proteins, peptides, RNA, and growth factors to target skin cells.
Exosomes regenerate and repair and play a role in hydration and barrier repair by:
- Stimulating natural hyaluronic acid production to improve moisture retention.
- Enhancing skin regeneration and encouraging renewal of the stratum corneum.
- Supporting barrier function through promoting lipid synthesis and cellular communication.
- Reducing inflammation and oxidative stress that can damage barrier integrity.
- Helping your skin produce more aquaporins, making it easier for it to stay hydrated and function at its best.
Which Skin Types and Concerns Benefit Most from Exosomes?
Dry or dehydrated skin: Needing deeper rejuvenation
Sensitive or compromised skin: Like rosacea, or eczema-prone skins or after medical aesthetic procedures like microneedling, laser, or peels
Aging and thinning skin: That needs support for reduced barrier function and moisture retention
As well as post-inflammatory concerns, such as scarring and pigmentation.
What Are the Best Skincare Formulations for Exosomes?
- Serums and ampoules optimize their bioactive delivery.
- Regenerative creams for repair and recovery.
- Post-procedure skincare products, like serums, creams, and masks to accelerate healing (after peels, lasers, and microneedling).
- Encapsulated formulations, which preserve exosome activity and improve their stability
Smart Ingredient Allies: What Works Best with Exosomes?
Exosomes work especially well with:
Growth factors & peptides: For amplified cellular communication and repair
Ceramides & fatty acids: To rebuild the skin barrier
Niacinamide: To calm inflammation and enhance skin resilience
Hyaluronic acid: To hydrate the skin while exosomes promote deeper repair
Panthenol or allantoin: For additional soothing and recovery
Your Skin Hydration Strategy: Insights for Smarter Product Selection and Use
Choosing the Right Products
When it comes to building a successful hydration-focused routine, knowing your ingredients and how to apply products is only half the story.
Product effectiveness depends on the formulation, the skin delivery system, and the packaging.
A delivery system refers to how well a product can transport its active ingredients into the layers of the skin where they’re needed most. It determines whether that hydrating serum just sits on the skin’s surface or actually penetrates and makes a difference.
Molecule size, ingredient solubility, encapsulation technologies (like liposomes or nanocarriers), and whether the formula is water or oil based all determine how ingredients absorb and how deeply they penetrate.
Serums vs. Creams: It’s All in the Delivery
Serums are lightweight and fast-absorbing, usually water-based, and packed with a high concentration of active ingredients. This makes them ideal for humectants, aquaporin-boosters, and barrier-repair actives that need to penetrate deeper into the skin.
Look for hydrating serums with glycerin, hyaluronic acid, or niacinamide, layer them at the start of your routine under heavier products.
Creams and moisturizers are more emollient or occlusive in nature. They often contain oils, ceramides, or butters that help strengthen the skin barrier and seal in moisture. These are perfect for the last steps of your routine, especially in the evening or during colder months when trans-epidermal water loss is higher.
Remember that most routines benefit from both types of products, layered appropriately.
Serums: |
Creams: |
Lightweight texture. Usually, water or gel based. |
Richer, thicker texture |
High humectant concentration |
Rich in emollients or occlusives |
May contain aquaporin boosting and barrier strengthening ingredients |
Emollients may contain aquaporin boosting and barrier strengthening ingredients |
Deep hydration delivery |
Barrier strengthening and seals in moisture |
Fast absorbing |
Longer lasting |
Read Ingredient Labels Like a Pro
Go beyond looking at the marketing claims on the front of the label to have a better understanding of what’s in your product.
Start by scanning the ingredient list to see where key hydrators fall. Ingredients are listed in descending order by concentration, so if hyaluronic acid, glycerin, or urea are near the top (or beginning), they’re likely playing a major role in the formula.
Keep in mind that some actives are effective even in lower concentrations (like ceramides or peptides), especially when supported by complementary ingredients.
Look for synergistic blends—humectants paired with emollients and occlusives—or barrier-repair ingredients included alongside hydration boosters.
Watch for potential irritants (especially if you’re working with sensitive skin), and always consider the formulation, not just the catchwords on the front label.

When to Splurge vs. When to Save
Not every product in your routine needs a luxury price tag. Here are tips to help you choose how to invest in your products:
Save on: Basic humectant serums (like glycerin or hyaluronic acid), gentle cleansers, or simple moisturizers—especially when they have short ingredient lists and minimal actives.
Splurge on: Products with advanced delivery systems, high-performing peptides, multiple weight hyaluronic acid, multi-functional serums, or those that combine hydration with treatment benefits (like antioxidant or brightening properties).
These often have more research behind them and are worth the investment, particularly if they form a core part of your routine.
The Experts Guide to Use Hydrating Products
You understand how hydrating ingredients work, along with how to choose products; now the next step is how to apply them effectively.
It seems obvious, you put them on your skin, right?
Building a hydration-focused skincare routine that works isn’t just about what you use—it’s about when and how you use it. With thoughtful layering, smart timing, and ingredient synergy, you can get the most out of every drop.
Morning vs. Evening: When to Use What
Your skin has different needs depending on the time of day.
Morning routines should focus on hydrating, protecting, and preparing the skin for environmental stressors.
This is where lightweight humectants, barrier-supporting serums, and antioxidants shine—followed by an emollient or light occlusive if needed, then sunscreen, which is non-negotiable (UV exposure is a major factor that contributes to dehydration).
Evening is when your skin enters repair and recovery mode. Focus on moisture retention and barrier support.
Richer textures, lipid-replenishing emollients, and deeper occlusives help seal in hydration overnight. Aquaporin-boosting ingredients and peptides also work well here, supporting cellular communication and water distribution as you sleep. If your skin is very dry, finish off with a richer occlusive to seal everything in.
Sun Sensitivity: What to Watch Out For
Some hydration-supporting ingredients can increase photosensitivity. Alpha hydroxy acids (AHAs) like lactic acid, and glycolic acid, and even urea in high concentrations can make skin more vulnerable to UV damage. For this reason, it’s best to use them in your evening routine.
Layering Strategy
When you apply your hydrating products, you’ll do so in layers. Remember, you’ll start with humectants, follow with emollients and finish with occlusives.
The golden rule is to go from the thinnest texture to thickest. This ensures water-based ingredients penetrate the skin and then the heavier ones lock them in. A typical hydration-focused order looks like this:
- Hydrating mist or essence (optional, but great for boosting absorption)
- Water-based serums (think humectants, aquaporin-boosters)
- Barrier-supporting serums or emulsions (lightweight emollients or ceramide-based treatments)
- Moisturizer (a blend of humectants + emollients, tailored to your skin type)
- Occlusive layer (as needed—especially for dry, dehydrated, or compromised skin)
- SPF (AM only, always)
This sequence mimics your skin’s natural moisture barrier and ensures each layer has a purpose.
📌 Pro Tip: When you apply serums or moisturisers, try patting them in when your skin is still slightly damp, not wet. (Either after cleansing or misting your skin with toner.)
It's a small tweak that can make your routine a lot more effective because it helps your skin absorb products better.
The moisture softens the surface of your skin and makes it more receptive to ingredients, especially hydrophilic ones like humectants. It makes humectants work easier and more effectively, because they can bind to the water on the surface of the skin and boost hydration.
Products are also easier to spread and help your skin get more out of each drop.
Timing Between Products
You don’t need to wait long between steps, but give each product 30 seconds to a minute to penetrate the skin. It allows actives to settle and helps prevent pilling. During the day, it also helps with smooth makeup application and, in the evening, prevents products rubbing off on your pillow. (If a product pills or feels tacky, that’s a sign to give it a little more time or reduce the amount used.)
Lightweight serums absorb quickly, but if you’re using heavier creams or oils, a bit of patience helps everything layer more smoothly.
Ingredient Combinations: What Works (and What Doesn’t)
Hydrating ingredients often work best in pairs or groups. Some proven power combos include:
Glycerin + Hyaluronic Acid: Glycerin draws water into the skin and helps hold on to it; HA adds plumpness and slip.
Glycerin + Ceramides: Humectant meets barrier-repair—plump and protect.
Aquaporin boosters + Humectants: Help distribute water more efficiently through the layers of the skin.
Niacinamide + Hyaluronic Acid: Supports hydration, barrier function, and tone—even for sensitive skin.
Niacinamide + Urea: Both support barrier function while boosting hydration and reducing sensitivity.
Ceramides + Fatty Acids + Cholesterol: The holy trinity for rebuilding the skin barrier.
But not all combinations play nicely. While most hydrating ingredients complement each other, certain combinations can interfere with hydration:
Exfoliants + too many humectants in dry environments: Can draw moisture out of the skin if there’s no occlusive to seal it in.
High-strength actives + barrier-repairing ingredients: It’s better to alternate these rather than stack them so you don’t overstimulate the skin.
Occlusives under makeup (for oily or combination skins): May lead to congestion or texture issues if too heavy.
Heavy occlusives before humectants or serums will block absorption of the active ingredients.
Multiple exfoliants (like lactic acid + glycolic acid) can strip the barrier, worsen dehydration, and lead to sensitivity.
Create Your Personal Hydration Routine
The way you hydrate your skin isn’t the same for everyone. Neither will you stick to the same routine all the time.
A serum that works wonders for dry winter skin might feel too intense in humid summer weather—or totally wrong for oily, acne-prone types.
To get hydration right, you need to adapt your approach based on your skin type, age, and even seasonal changes.
Here’s what you need to consider:
Adapt to Your Skin Type
Earlier we looked at ‘Expert Tips on Layering for Different Skin Types’. Choose and use products that support and enhance your skin type (and remember it’s equally important to adjust them when your skin experiences changes).
Bonus Tips to Hydrate your Skin Like an Expert:
Oily Skin:
Hydration is still essential, don’t skip it. Choose lightweight, non-comedogenic humectants like glycerin or hyaluronic acid in gel serums.
Use barrier-supporting ingredients in a serum rather than heavy creams. If you need occlusives (like during retinol use), go for permeable options like dimethicone or jojoba oil, and apply them sparingly.
Combination Skin:
Apply richer emollients or occlusives to drier areas (usually cheeks) and use lightweight formulations on oily areas (like the T-zone).
Hydrating mists are a great option to help top up moisture throughout the day without overloading oily patches.
Dry Skin:
Layer hydration into every step of your routine. Start with a humectant-rich essence or serum (like glycerin or hyaluronic acid), follow with a barrier-repairing emollient cream (think ceramides, fatty acids), and seal it in with a gentle occlusive.
Creamy textures and richer balms are beneficial, especially at night.
Sensitive Skin:
Stick to formulations with fewer ingredients, to reduce the chance of irritation.
Prioritize barrier-repairing ingredients like niacinamide, beta-glucan, and ceramides.
Avoid overly fragrant products or those with high concentrations of active acids. Hydration should soothe and restore the skin and not trigger reactivity.
Age-Specific Strategies
20s–30s: Preventative Care
This is the time to build habits that support and protect your skin hydration long-term.
Daily humectants and barrier support (like light ceramide serums) help preserve skin elasticity, maintain barrier function, and prevent premature dehydration.
40s–50s: Strengthen and Maintain Hydration
During this time your skin’s natural lipid and moisture content declines.
Hydration strategies should focus on combining humectants with more emollient support and barrier strengthening boosters like cholesterol and fatty acids.
Your aim is to boost water and lipid levels in your skin, support and maintain long term hydration processes, and strengthen your skin barrier function.
60+: Intensive Care
Your skin usually becomes thinner, drier, and more prone to trans-epidermal water loss (TEWL).
Use deeply hydrating formulas with multi-layer support like hydrating serums, rich barrier creams, and well-tolerated occlusives.
Products that deliver long-lasting comfort and help reduce irritation will offer the most visible improvements and slow down skin aging.
Seasonal Adjustments
Summer:
Heat and humidity can make your skin feel more hydrated than it actually is. It’s easy to think you can skip serums or moisturisers, but doing so can disrupt your skin’s oil and moisture balance, leading to dehydration.
Besides heat and sun exposure, indoor cooling systems can also strip moisture from the skin.
Use lightweight, water-based serums and emulsions. Ingredients like panthenol, and glycerin provide effective hydration without feeling heavy or greasy.
And don’t skip sunscreen, many modern formulas now double as hydrating moisturizers.
Winter:
Cold weather and indoor heating can quickly strip moisture from the skin, leaving it dry and vulnerable.
Your skin still needs humectants, aquaporin boosters, and barrier-repairing ingredients—but winter is also the time to bring in richer emollients and thicker occlusives.
Look for creamier textures and more nourishing formulas to seal in moisture, prevent trans-epidermal water loss (TEWL), and shield the skin from harsh weather and dry indoor air.
Transitional Season Adjustments for Spring and Fall
As the seasons change, notice how your skin responds to weather and humidity fluctuations.
Gradually adjust your routine to prepare your skin for the upcoming season so it stays well hydrated despite the changing environment.
Humidity and Your Skin:
The amount of moisture in the air directly affects your skin’s hydration levels.
Keep this in mind:
- High humidity: Your skin draws more moisture from the air, so humectants work well. Lighter products that hydrate the skin’s surface are especially effective.
- Low humidity: Humectants may pull water from deeper within the skin instead of the air, which can increase dehydration. Always pair them with an occlusive to seal in moisture. A humidifier can also help reduce water loss and maintain hydration.
The most effective hydration routine adapts with your skin. When you understand what your skin needs—and how those needs change over time and with the environment—you can personalise your routine to keep it working in synergy with your skin.
More Than Products: What Your Skin Needs Beyond Skincare
Hydration isn’t just about what you put on your skin. While your skincare routine is essential, several other lifestyle factors play a big role in how well your skin holds onto moisture.
Let’s look at other factors that also play an important role:
Internal Hydration Helps (But It’s Not the Whole Story)
Drinking enough water is important for overall health and helps hydrate deeper tissues. But the outermost layers of your skin don’t get moisture directly from what you drink—that’s where your skincare comes in.
Think of it like the earth: underground water sources matter, but if there’s no rain, the surface still dries out. Skincare works from the surface, helping to supply moisture at the surface, seal it in, and protect your skin from environmental stress.
Keeping your body hydrated helps the overall functioning of your skin so it can maintain optimum performance and reduce stress factors that contribute to water loss and barrier dysfunction.
Nutrition and Healthy Fats
What you eat matters to your skin. A strong skin barrier needs healthy fats to retain moisture, and a diet rich in omega-3s, antioxidants, and vitamin E supports this from within.
Great skin-friendly foods include:
- Fatty fish, like salmon
- Avocados and nuts
- Chia seeds and flaxseeds
- Colorful fruits and vegetables
These all help nourish your barrier and support hydration naturally.
Sleep and Skin Recovery
Your skin does its best repair work while you sleep, including restoring moisture balance and barrier strength.
Poor sleep can disrupt this process, leading to increased trans-epidermal water loss (TEWL), dehydration, and dull skin. Getting enough rest helps your skin stay hydrated and resilient.
Environmental Factors
Environmental factors like heating, air conditioning, wind, and humidity have a huge impact on hydration levels.
In low humidity, your skin loses moisture quickly; in high humidity, it may feel more hydrated, but it still needs proper care. This is when it needs lightweight, water-based products need to help maintain hydration balance and protect against environmental stressors.
UV Exposure
UV rays not only damage collagen—they also dehydrate the skin and weaken its barrier.
Protecting your skin from the sun helps it retain moisture and prevent dehydration.
Daily SPF is essential, even on cloudy days, along with protecting your skin with clothing and shady spaces.
Stress and Your Skin
High stress levels increase cortisol in your body, which can thin your barrier, trigger inflammation, and make skin more prone to dehydration.
If you're going through a stressful time, use soothing, barrier-repairing products and follow a gentle skincare routine.
Product Habits That Affect Hydration
How you use your products matters:
- Over-cleansing or overusing strong actives can strip moisture.
- Applying humectants without sealing them in—especially in dry air—can actually draw moisture out of your skin.
Focus on consistency, notice how your skin feels, and use a balanced routine that supports hydration rather than working against it.
The Final Word on Smart Hydration …
Hydrated skin is happy skin. From your cleanser to your night cream, it’s not about using more—it’s about using smarter. Now that you know what contributes to each element of skin hydration, you can build a routine that works with your skin. Remember, hydration doesn’t have to be complicated, it just has to be consistent.
Do you have thoughts or questions you want to share with us about your hydration routine? Share them with us in the comments below.
Clinical Studies Referenced:
1:https://jcadonline.com/fundamentals-of-skin-barrier-physiology/
2:https://pubmed.ncbi.nlm.nih.gov/33196748/
3:https://www.dermatologyadvisor.com/news/otc-skin-care-effects-on-acne/